Structures of virus receptors

​We have worked out four virus receptor structures, including CD4, the primary receptor for HIV, ICAM-1, the receptor for human rhinovirus, VCAM-1, the receptor for mouse encephalomyocarditis, and CEACAM1a, the mouse hepatitis virus receptor. We have discovered how these similar-looking proteins are subverted to receptors for different viruses. Our structural studies on these extremely important receptors have had a good impact on the medical research and pharmaceutical circle. We would like to go on this line, working on other virus receptors.