Major Publications
Please click here for a complete list of publications.
Chen X, Zhao C, Li, X-L, Wang, T, Li Y, Cao. C, Ding, Y, Dong, M, Finci, L, Wang JH, Li, X and Liu. L. Terazosin can activate Pgk1 and Hsp90 to promote stress resistance. Nature, Chem. Biol., 2014.
Finci L, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH and Meijers R. The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue. Neuron, 2014, 83:839-849
Chen Q, Sun X, Zhou HX, Liu JH, Wu J, Zhang Y and Wang JH. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J. Cell Science, 2013; 126: 186-195
Schurpf T, Chen Q, Liu JH, Wang R, Springer TA, and Wang JH. The RGD finger of Del-1 is a unique structural feature critical for integrin inding. The FASEB Journal, 2012; 26: 3412-20
Wang, JH and Reinherz, E.L. The structural basis of ab T lineage immune recognition: TCR docking topologies, mechanotransduction and co-receptor function. Immunological Review, 2012; 250: 102-119
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu J-H, Walz T, Wang JH and Schmucker D. Structural Basis of Dscam Isoform specificity. Nature, 2007; 449: 487-491.
Chang HC, Tan K, Ouyang J, Parisini E, Liu J-H, Le L, Wang X, Reinherz EL and Wang JH. Structural and mutational analyses of a CD8αβ heterodimer and comparison with CD8αα homodimer. Immunity, 2005; 23: 661-671
Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, Springer TA and Wang JH. An Atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2. Proc Natl Acad Sci USA. 2005; 102: 3366-3371
Xiao T, Takagi J, Coller BS, Wang JH and Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature, 2004; 432: 59-67
Yang Y, Jun CD, Liu JH, Zhang R, Jochimiak, A, Springer TA and Wang JH. Structural basis for dimerization of ICAM-1 on the cell surface. Mol. Cell. 2004, 14:269-276.
Springer TA and Wang JH, The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Advances in Prot. Chem. 2004; Volume 68 ed. Garcia, K. C., Elsevier, San Diego, CA. pp 29-63.
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J and Wang JH and Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003; 112: 99-111.
Wang JH. Protein recognition by cell surface receptors: physiological receptors versus virus interactions. Trends in Biochemical Sciences. 2002; 27:122-126.
Tan K, Duquette M, Liu J-H, Dong Y, Zhang R, Joachimiak A, Lawler J and Wang JH. Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol. 2002; 159:373-382.
Tan K, Zelus BD, Meijers R, Liu JH, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV and Wang JH. Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. EMBO J. 2002; 21:2076-2086.
Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A and Reinherz EL. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci USA 2001; 98:10799-10804.
Reinherz EL, Tan K, Tang L, Kern P, Liu JH, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, and Wang JH. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 1999; 286:1913-1921.
Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZJ, Wagner G and Reinherz EL. Structure of a heterophilic adhesion complex between human CD2 and CD58 (LFA-3) counterreceptors. Cell 1999; 97:791-803.
Chen X, Zhao C, Li, X-L, Wang, T, Li Y, Cao. C, Ding, Y, Dong, M, Finci, L, Wang JH, Li, X and Liu. L. Terazosin can activate Pgk1 and Hsp90 to promote stress resistance. Nature, Chem. Biol., 2014.
Finci L, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH and Meijers R. The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue. Neuron, 2014, 83:839-849
Chen Q, Sun X, Zhou HX, Liu JH, Wu J, Zhang Y and Wang JH. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J. Cell Science, 2013; 126: 186-195
Schurpf T, Chen Q, Liu JH, Wang R, Springer TA, and Wang JH. The RGD finger of Del-1 is a unique structural feature critical for integrin inding. The FASEB Journal, 2012; 26: 3412-20
Wang, JH and Reinherz, E.L. The structural basis of ab T lineage immune recognition: TCR docking topologies, mechanotransduction and co-receptor function. Immunological Review, 2012; 250: 102-119
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu J-H, Walz T, Wang JH and Schmucker D. Structural Basis of Dscam Isoform specificity. Nature, 2007; 449: 487-491.
Chang HC, Tan K, Ouyang J, Parisini E, Liu J-H, Le L, Wang X, Reinherz EL and Wang JH. Structural and mutational analyses of a CD8αβ heterodimer and comparison with CD8αα homodimer. Immunity, 2005; 23: 661-671
Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, Springer TA and Wang JH. An Atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2. Proc Natl Acad Sci USA. 2005; 102: 3366-3371
Xiao T, Takagi J, Coller BS, Wang JH and Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature, 2004; 432: 59-67
Yang Y, Jun CD, Liu JH, Zhang R, Jochimiak, A, Springer TA and Wang JH. Structural basis for dimerization of ICAM-1 on the cell surface. Mol. Cell. 2004, 14:269-276.
Springer TA and Wang JH, The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Advances in Prot. Chem. 2004; Volume 68 ed. Garcia, K. C., Elsevier, San Diego, CA. pp 29-63.
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J and Wang JH and Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003; 112: 99-111.
Wang JH. Protein recognition by cell surface receptors: physiological receptors versus virus interactions. Trends in Biochemical Sciences. 2002; 27:122-126.
Tan K, Duquette M, Liu J-H, Dong Y, Zhang R, Joachimiak A, Lawler J and Wang JH. Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol. 2002; 159:373-382.
Tan K, Zelus BD, Meijers R, Liu JH, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV and Wang JH. Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. EMBO J. 2002; 21:2076-2086.
Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A and Reinherz EL. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci USA 2001; 98:10799-10804.
Reinherz EL, Tan K, Tang L, Kern P, Liu JH, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, and Wang JH. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 1999; 286:1913-1921.
Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZJ, Wagner G and Reinherz EL. Structure of a heterophilic adhesion complex between human CD2 and CD58 (LFA-3) counterreceptors. Cell 1999; 97:791-803.